Targeting p38-MAPK in the ischaemic heart: kill or cure?

被引：71

作者：

Bassi, Rekha ^{[1
]}

Heads, Richard ^{[1
]}

Marber, Michael S. ^{[1
]}

Clark, James E. ^{[1
]}

机构：

[1] St Thomas Hosp, Rayne Inst, Univ London Kings Coll, Dept Cardiol,Cardiovasc Div, London SE1 7EH, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2008年 / 8卷 / 02期

关键词：

D O I：

10.1016/j.coph.2008.01.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The p38-MAPK pathway plays an important role in myocardial ischaemia/reperfusion injury and has been implicated in the regulation of cardiac gene expression, myocyte hypertrophy, inflammation, energetic metabolism, contractility, proliferation and apoptosis. The activation of p38-MAPK by dual phosphorylation during myocardial ischaemia aggravates lethal injury. However, under other circumstances activation can protect the heart, and recent evidence suggests that the mechanism of p38-MAPK activation may differ by circumstance. Determining the precise mechanism of activation during myocardial ischaemia is of considerable importance, since it may allow prevention of the detrimental, but not the beneficial, activation of p38-MAPK and lead to the identification of the relevant signalling molecules to be targeted for pharmaceutical intervention.

引用

页码：141 / 146

页数：6

共 72 条

[1] Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development [J].