Passive stiffness is increased in soleus muscle of desmin knockout mouse

被引：42

作者：

Anderson, J

Li, ZL

Goubel, F

机构：

[1] Unite Biomecan & Genie Biomed, UMR 6600 CNRS, F-60205 Compiegne, France

[2] Univ Technol Compiegne, F-60205 Compiegne, France

[3] Univ Denis Diderot Paris, Lab Biol Mol Differenciat, Paris, France

来源：

MUSCLE & NERVE | 2001年 / 24卷 / 08期

关键词：

desmin; mouse; passive stiffness; relaxation test; soleus;

D O I：

10.1002/mus.1115

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The effects of an absence of desmin on passive stiffness of skeletal muscle were analyzed using soleus muscles from desmin knockout mice. Stiffness was evaluated by analyzing the passive tension induced by a ramp-and-hold extension test. This test showed that passive resistance to stretch was largely increased for muscles lacking desmin. This study could facilitate interpretation of changes in muscle mechanics observed in humans affected by desmin-related myopathies. (C) 2001 John Wiley & Sons, Inc.

引用

页码：1090 / 1092

页数：3

共 21 条

[1] Basis of passive tension and stiffness in isolated rabbit myofibrils [J].