Right place, right time, and only once: Replication initiation in metazoans

被引：223

作者：

Machida, YJ ^{[1
]}

Hamlin, JL ^{[1
]}

Dutta, A ^{[1
]}

机构：

[1] Univ Virginia, Sch Med, Dept Mol Genet & Biochem, Charlottesville, VA 22908 USA

来源：

CELL | 2005年 / 123卷 / 01期

关键词：

D O I：

10.1016/j.cell.2005.09.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.

引用

页码：13 / 24

页数：12

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