Convergence of transforming growth factor-β and vitamin D signaling pathways on SMAD transcriptional coactivators

被引：393

作者：

Yanagisawa, J

Yanagi, Y

Masuhiro, Y

Suzawa, M

Watanabe, M

Kashiwagi, K

Toriyabe, T

Kawabata, M

Miyazono, K

Kato, S

机构：

[1] Japan Sci & Technol, CREST, Kawaguchi, Saitama 332, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

[3] Japanese Fdn Canc Res, Inst Canc, Dept Biochem, Toshima Ku, Tokyo 1708455, Japan

[4] Japan Soc Promot Sci, Res Future Program, Toshima Ku, Tokyo 1708455, Japan

来源：

SCIENCE | 1999年 / 283卷 / 5406期

关键词：

D O I：

10.1126/science.283.5406.1317

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for Ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-l protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways.

引用

页码：1317 / 1321

页数：5

共 44 条

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