Human papillomavirus type influences the extent of chromosomal lag during mitosis in cervical intraepithelial neoplasia grade III

被引:10
作者
Burger, MPM
VanLeeuwen, AM
Hollema, H
Quint, WGV
Pieters, WJLM
机构
[1] UNIV GRONINGEN HOSP,DEPT PATHOL,NL-9700 RB GRONINGEN,NETHERLANDS
[2] SSDZ,CTR DIAGNOST,DELFT,NETHERLANDS
[3] SSZOG,DEPT PATHOL,WINSCHOTEN,NETHERLANDS
关键词
cervical intraepithelial neoplasia; chromosomal lag; human papillomavirus; mitosis;
D O I
10.1097/00004347-199701000-00002
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The level of risk for carcinoma in the uterine cervix depends on the type of human papillomavirus (HPV) present. We examined whether the HPV type influences the proliferation rate and occurrence of mitotic figures with lagging chromosomes in the precursor of cervical carcinoma. The study group comprised 180 women who were referred because of cytologic changes indicating dysplasia and who were subsequently diagnosed with cervical intraepithelial neoplasia grade III. The HPV-16-associated lesions showed a significantly higher number of mitoses per 1,000 nuclei than the lesions without HPV (p < 0.001). The HPV-16-associated lesions also showed a significantly higher proportion of mitotic figures with lagging chromosomes than did the HPV-18- or HPV-31-associated lesions and lesions without HPV (p = 0.01, p = 0.007, and p = 0.002, respectively). Our results indicate that the differences in oncogenic potential among HPVs become apparent in the precursor lesion through the differences in the extent of chromosomal lag during mitosis.
引用
收藏
页码:10 / 14
页数:5
相关论文
共 25 条
[1]   MITOSIS COUNTING IN TUMORS [J].
BAAK, JPA .
HUMAN PATHOLOGY, 1990, 21 (07) :683-685
[2]   HUMAN PAPILLOMAVIRUSES ASSOCIATED WITH CERVICAL INTRAEPITHELIAL NEOPLASIA - GREAT DIVERSITY AND DISTINCT DISTRIBUTION IN LOW-GRADE AND HIGH-GRADE LESIONS [J].
BERGERON, C ;
BARRASSO, R ;
BEAUDENON, S ;
FLAMANT, P ;
CROISSANT, O ;
ORTH, G .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1992, 16 (07) :641-649
[3]  
BRAND E, 1988, OBSTET GYNECOL, V71, P261
[4]   PREDICTIVE VALUE OF HUMAN PAPILLOMAVIRUS TYPE FOR HISTOLOGICAL DIAGNOSIS OF WOMEN WITH CERVICAL CYTOLOGICAL ABNORMALITIES [J].
BURGER, MPM ;
HOLLEMA, H ;
PIETERS, WJLM ;
QUINT, WGV .
BRITISH MEDICAL JOURNAL, 1995, 310 (6972) :94-95
[5]   THE RELIABILITY OF THE HISTOLOGIC DIAGNOSIS IN COLPOSCOPICALLY DIRECTED BIOPSIES - A PLEA FOR LETZ [J].
BURGER, MPM ;
HOLLEMA, H .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 1993, 3 (06) :385-390
[6]  
INGELFINGER JA, 1983, BIOSTATISTICS CLIN M, P169
[7]   OBSERVER VARIATION IN HISTOPATHOLOGICAL DIAGNOSIS AND GRADING OF CERVICAL INTRAEPITHELIAL NEOPLASIA [J].
ISMAIL, SM ;
COLCLOUGH, AB ;
DINNEN, JS ;
EAKINS, D ;
EVANS, DMD ;
GRADWELL, E ;
OSULLIVAN, JP ;
SUMMERELL, JM ;
NEWCOMBE, RG .
BRITISH MEDICAL JOURNAL, 1989, 298 (6675) :707-710
[8]   HUMAN PAPILLOMAVIRUS-16 E6 EXPRESSION DISRUPTS THE P53-MEDIATED CELLULAR-RESPONSE TO DNA DAMAGE [J].
KESSIS, TD ;
SLEBOS, RJ ;
NELSON, WG ;
KASTAN, MB ;
PLUNKETT, BS ;
HAN, SM ;
LORINCZ, AT ;
HEDRICK, L ;
CHO, KR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) :3988-3992
[9]  
KIVIAT NB, 1992, EPIDEMIOLOGY CERVICA, P59
[10]   HUMAN PAPILLOMAVIRUS INFECTION OF THE CERVIX - RELATIVE RISK ASSOCIATIONS OF 15 COMMON ANOGENITAL TYPES [J].
LORINCZ, AT ;
REID, R ;
JENSON, AB ;
GREENBERG, MD ;
LANCASTER, W ;
KURMAN, RJ .
OBSTETRICS AND GYNECOLOGY, 1992, 79 (03) :328-337