Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!

被引：95

作者：

Borlongan, C. V. ^{[1
]}

机构：

[1] Univ S Florida, Coll Med, Dept Neurosurg & Brain Repair, Tampa, FL USA

来源：

LEUKEMIA | 2011年 / 25卷 / 11期

关键词：

stroke; cell therapy; migration; homing; neurogenesis; angiogenesis; ENDOTHELIAL PROGENITOR CELLS; UMBILICAL-CORD BLOOD; ACUTE MYOCARDIAL-INFARCTION; CEREBRAL-ARTERY OCCLUSION; HUMAN CD34(+) CELLS; STROMAL CELLS; PERIPHERAL-BLOOD; THERAPEUTIC BENEFIT; FUNCTIONAL RECOVERY; INTRACEREBRAL TRANSPLANTATION;

D O I：

10.1038/leu.2011.167

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Mobilizing bone cells to the head, astutely referred to as 'bonehead' therapeutic approach, represents a major discipline of regenerative medicine. The last decade has witnessed mounting evidence supporting the capacity of bone marrow (BM)-derived cells to mobilize from BM to peripheral blood (PB), eventually finding their way to the injured brain. This homing action is exemplified in BM stem cell mobilization following ischemic brain injury. Here, I review accumulating laboratory studies implicating the role of therapeutic mobilization of transplanted BM stem cells for brain plasticity and remodeling in stroke. Leukemia (2011) 25, 1674-1686; doi:10.1038/leu.2011.167; published online 5 July 2011

引用

页码：1674 / 1686

页数：13

共 198 条

[1]

The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche [J].

Aicher, Alexandra ;

Kollet, Orit ;

Heeschen, Christopher ;

Liebner, Stefan ;

Urbich, Carmen ;

Ihling, Christian ;

Orlandi, Alessia ;

Lapidot, Tsvee ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION RESEARCH, 2008, 103 (08) :796-803

[2]

Isolation of putative progenitor endothelial cells for angiogenesis [J].

Asahara, T ;

Murohara, T ;

Sullivan, A ;

Silver, M ;

vanderZee, R ;

Li, T ;

Witzenbichler, B ;

Schatteman, G ;

Isner, JM .

SCIENCE, 1997, 275 (5302) :964-967

[3]

Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[4]

Intravenous basic fibroblast growth factor (bFGF) decreases DNA fragmentation and prevents downregulation of Bcl-2 expression in the ischemic brain following middle cerebral artery occlusion in rats [J].

Ay, I ;

Sugimori, H ;

Finklestein, SP .

MOLECULAR BRAIN RESEARCH, 2001, 87 (01) :71-80

[5]

Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain [J].

Bachstetter, Adam D. ;

Pabon, Mibel M. ;

Cole, Michael J. ;

Hudson, Charles E. ;

Sanberg, Paul R. ;

Willing, Alison E. ;

Bickford, Paula C. ;

Gemma, Carmelina .

BMC NEUROSCIENCE, 2008, 9 (1) :22

[6]

Updates on stem cells and their applications in regenerative medicine [J].

Bajada, Stefan ;

Mazakova, Irena ;

Richardson, James B. ;

Ashammakhi, Nureddin .

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2008, 2 (04) :169-183

[7]

Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy [J].

Banfi, A ;

Muraglia, A ;

Dozin, B ;

Mastrogiacomo, M ;

Cancedda, R ;

Quarto, R .

EXPERIMENTAL HEMATOLOGY, 2000, 28 (06) :707-715

[8]

Autologous mesenchymal stem cell transplantation in stroke patients [J].

Bang, OY ;

Lee, JS ;

Lee, PH ;

Lee, G .

ANNALS OF NEUROLOGY, 2005, 57 (06) :874-882

[9]

Stem cell paracrine actions and tissue regeneration [J].

Baraniak, Priya R. ;

McDevitt, Todd C. .

REGENERATIVE MEDICINE, 2010, 5 (01) :121-143

[10]

Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain [J].

Benraiss, A ;

Chmielnicki, E ;

Lerner, K ;

Roh, D ;

Goldman, SA .

JOURNAL OF NEUROSCIENCE, 2001, 21 (17) :6718-6731

← 1 2 3 4 5 6 7 8 9 10 →