Inhibitory effect of aucubin isolated from Eucommia ulmoides against UVB-induced matrix metalloproteinase-1 production in human skin fibroblasts

被引：45

作者：

Ho, JN

Lee, YH

Lee, YD

Jun, WJ

Kim, HK

Hong, BS

Shin, DH

Cho, HY ^{[1
]}

机构：

[1] Korea Univ, Grad Sch Life Sci & Biotechnol, Dept Food Technol, Seoul 136701, South Korea

[2] Korea Food & Drug Adm, Div Food Contaminant, Seoul 122051, South Korea

[3] Chonnam Natl Univ, Dept Food & Nutr, Kwangju 500757, South Korea

[4] Hanseo Univ, Dept Food & Biotechnol, Seosan 356706, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 11期

关键词：

fibroblast; ultraviolet B (UVB); Eucommia ulmoides; aucubin; matrix metalloproteinase-1 (MMP-1);

D O I：

10.1271/bbb.69.2227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Of 30 herbal plants tested, the methanol extracts of Eucommia ulmoides (52%), Evodia officinalis (45%), and Pleuropterus multiflorus (41%) each showed a potent inhibitory effect on the matrix metalloproteinase-1 (MMP-1) production in ultraviolet B (UVB)-irradiated human fibroblasts. Aucubin was isolated as the MMP-1 inhibitor from E. ulmoides, and significantly suppressed the production of MMP-1 by nearly 57% compared to the control. It also reduced MMP-1 mRNA expression. These results suggest that aucubin is a photoprotective phytochemical, and could be used as a potential agent in preventing photoaging.

引用

页码：2227 / 2231

页数：5

共 25 条

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