A correlation between HLA-C matching and donor antirecipient CTL precursor frequency in bone marrow transplantation

被引：25

作者：

Barnardo, MCNM ^{[1
]}

Davey, NJ ^{[1
]}

Bunce, M ^{[1
]}

Brookes, PA ^{[1
]}

Lechler, RI ^{[1
]}

Welsh, KI ^{[1
]}

Batchelor, JR ^{[1
]}

机构：

[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,LONDON W12 0NN,ENGLAND

来源：

TRANSPLANTATION | 1996年 / 61卷 / 09期

关键词：

D O I：

10.1097/00007890-199605150-00027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A newly developed, reliable, DNA-based method for typing for alleles of the HLA-C locus has been applied in the context of unrelated, volunteer donors for bone marrow transplantation. Some donors matched for HLA-A -B, -DR, and -DQ have been found to generate in vitro high frequencies of CTL reactive with the recipient's cells. Here we demonstrate that there is a highly significant correlation of the frequencies of CTL precursors and incompatibility at the HLA-C locus. These data indicate that HLA-C locus incompatibility should be avoided in unrelated donor bone marrow transplantation.

引用

页码：1420 / 1423

页数：4

共 13 条

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