ERp57, a multifunctional endoplasmic reticulum resident oxidoreductase

被引：123

作者：

Coe, Helen ^{[1
,2
]}

Michalak, Marek ^{[1
,2
]}

机构：

[1] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

[2] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2H7, Canada

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 06期

基金：

加拿大健康研究院;

关键词：

Endoplasmic reticulum; Oxidoreductase; STAT3; Protein folding; ERp57; PROTEIN DISULFIDE-ISOMERASE; GLUCOSE-REGULATED PROTEIN; MOLECULAR-CLONING; CRYSTAL-STRUCTURE; CALRETICULIN; CALNEXIN; CELLS; EXPRESSION; COMPLEXES; DOMAINS;

D O I：

10.1016/j.biocel.2010.01.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

ERp57 is a 58-kDa thiol oxidoreductase and a member of the protein disulfide isomerase (PDI)-like family. ERp57 is highly similar to other PDI family members in terms of amino acid sequence and structural/functional domain organization; however, It possesses some distinctive structural features that dictate its unique functions in the cell This protein plays an important role in endoplasmic reticulum quality control of newly synthesized glycoproteins, is critical in major histocompatability complex (MHC) class I assembly and regulates gene expression. Studies on ERp57-deficient mice indicate that the protein is critical during embryonic development The protein has been implicated in human pathologies including cancer and Alzheimer's disease. (C) 2010 Elsevier Ltd. All rights reserved

引用

页码：796 / 799

页数：4

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