The earliest behavioral expression of focal damage to human prefrontal cortex

被引:14
作者
Anderson, Steven W.
Aksan, Nazan
Kochanska, Grazyna
Damasio, Hanna
Wisnowski, Jessica
Afifi, Adel
机构
[1] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA
[3] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA
[4] Univ Iowa, Dept Anat & Cell Biol, Iowa City, IA 52242 USA
关键词
prefrontal cortex; emotion; attention; executive function;
D O I
10.1016/S0010-9452(08)70508-2
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
Damage to the prefrontal cortex in childhood can produce long-term impairments of emotion, behavior regulation, and executive functions, but little is known regarding the earliest expression of these impairments. We describe here detailed behavioral studies of a boy at 14 months of age ('PF1') who sustained focal damage in the right inferior dorsolateral prefrontal cortex due to resection of a vascular malformation on day 3 of life. The surgery was followed by a good medical recovery, and he reached developmental milestones at a normal rate. His neurological examination was normal, as were his mother's ratings of communication abilities, daily living skills, socialization, and motor skills. Multiple standardized laboratory paradigms were used to evaluate his behavior in structured and relatively unstructured situations designed to elicit positive and negative emotions and to place demands on attention. Relative to a comparison group of 50 age-matched boys with no neurological history, PF1 demonstrated significant impairments in the regulation of emotion and engagement of attention, particularly in unstructured conditions. These findings indicate that damage to prefrontal cortex in infancy begins to impact on emotional and cognitive development already during the first months of life.
引用
收藏
页码:806 / 816
页数:11
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