The core transcriptome of mammalian placentas and the divergence of expression with placental shape

被引：43

作者：

Armstrong, Don L. ^{[1
]}

McGowen, Michael R. ^{[2
]}

Weckle, Amy ^{[1
]}

Pantham, Priyadarshini ^{[1
]}

Caravas, Jason ^{[3
]}

Agnew, Dalen ^{[4
]}

Benirschke, Kurt ^{[5
]}

Savage-Rumbaugh, Sue ^{[6
]}

Nevo, Eviatar ^{[14
]}

Kim, Chong J. ^{[7
,8
]}

Wagner, Gunter P. ^{[12
]}

Romero, Roberto ^{[7
,9
,10
,11
]}

Wildman, Derek E. ^{[1
,6
,13
]}

机构：

[1] Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA

[2] Queen Mary Univ London, Sch Biol & Chem Sci, London, England

[3] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI USA

[4] Michigan State Univ, Coll Vet Med, Diagnost Ctr Populat & Anim Hlth, E Lansing, MI 48824 USA

[5] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[6] Bonobo Hope Sanctuary, Great Ape Trust, Des Moines, IA USA

[7] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, NIH, Detroit, MI USA

[8] Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul, South Korea

[9] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA

[10] Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA

[11] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI USA

[12] Yale Univ, Dept Ecol & Evolutionary Biol, Yale Syst Biol Inst, New Haven, CT USA

[13] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL USA

[14] Univ Haifa, Inst Evolut, Haifa, Israel

来源：

PLACENTA | 2017年 / 57卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Mammal; Gene expression; Evolution; RNA-Seq; Placenta; EVOLUTION; GENES; HORMONE; GROWTH; PROFILES; PROTEINS; SEQUENCE; DATABASE;

D O I：

10.1016/j.placenta.2017.04.015

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Introduction: The placenta is arguably the most anatomically variable organ in mammals even though its primary function is conserved. Method: Using RNA-Seq, we measured the expression profiles of 55 term placentas of 14 species of mammals representing all major eutherian superordinal clades and marsupials, and compared the evolution of expression across clades. Results: We identified a set of 115 core genes which is expressed (FPKM > 10) in all eutherian placentas, including genes with immune-modulating properties (ANXA2, ANXA1, S100A11, S100A10, and LGALSI), cell-cell interactions (LAMC1, LUM, and LGALSI), invasion (GRB2 and RALB) and syncytialization (ANXA5 and ANXAI). We also identified multiple pre-eclampsia associated genes which are differentially expressed in Homo sapiens when compared to the other 13 species. Multiple genes are significantly associated with placenta morphology, including EREG and WNT5A which are both associated with placental shape. Discussion: 115 genes are important for the core functions of the placenta in all eutherian species analyzed. The molecular functions and pathways enriched in the core placenta align with the evolutionarily conserved functionality of the placenta. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：71 / 78

页数：8

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