Task-related EEG-EEG coherence depends on dopaminergic activity in Parkinson's disease

被引:21
作者
Cassidy, M
Brown, P
机构
[1] Inst Neurol, MRC, Human Movement & Balance Unit, London WC1N 3BG, England
[2] UCL Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England
关键词
basal ganglia; coherence; connectivity; motor control; Parkinson's disease;
D O I
10.1097/00001756-200103260-00018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We investigated whether functional coupling between different cortical areas is impaired in Parkinson's disease, using corticocortical coherence as a surrogate measure of coupling. We recorded scalp EEG from different sites in seven parkinsonian patients while they tracked a visual target using their wrist, or copied the same movement from memory. Differences in EEG-EEG coherence between the tracking and copying tasks and their respective controls, visual tracking alone and fixation of a stationary target, were determined on and off levodopa. After levodopa we found extensive task-specific and broad band cortico-cortical coherence. Off levodopa cortico-cortical coherence was much reduced. Ascending dopaminergic projections from the ventral mesencephalon may therefore be important in determining the pattern and extent of corticocortical coupling during executive tasks. NeuroReport 12:703-707 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码:703 / 707
页数:5
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