Multiple newly identified loci associated with prostate cancer susceptibility

被引：682

作者：

Eeles, Rosalind A. ^{[1
,2
,3
]}

Kote-Jarai, Zsofia ^{[1
]}

Giles, Graham G. ^{[4
,5
]}

Al Olama, Ali Amin ^{[6
]}

Guy, Michelle ^{[1
]}

Jugurnauth, Sarah K. ^{[1
]}

Mulholland, Shani ^{[1
]}

Leongamornlert, Daniel A. ^{[1
]}

Edwards, Stephen M. ^{[1
]}

Morrison, Jonathan ^{[6
]}

Field, Helen I. ^{[7
]}

Southey, Melissa C. ^{[8
]}

Severi, Gianluca ^{[4
,5
]}

Donovan, Jenny L. ^{[9
]}

Hamdy, Freddie C. ^{[10
]}

Dearnaley, David P. ^{[1
,2
,3
]}

Muir, Kenneth R. ^{[11
]}

Smith, Charmaine ^{[4
]}

Bagnato, Melisa ^{[4
]}

Ardern-Jones, Audrey T. ^{[2
,3
]}

Hall, Amanda L. ^{[1
,2
,3
]}

O'Brien, Lynne T. ^{[1
]}

Gehr-Swain, Beatrice N. ^{[1
,2
,3
]}

Wilkinson, Rosemary A. ^{[1
]}

Cox, Angie ^{[10
]}

Lewis, Sarah ^{[9
]}

Brown, Paul M. ^{[12
,13
]}

Jhavar, Sameer G. ^{[1
]}

Tymrakiewicz, Malgorzata ^{[1
]}

Lophatananon, Artitaya ^{[11
]}

Bryant, Sarah L. ^{[1
]}

Horwich, Alan ^{[1
,2
,3
]}

Huddart, Robert A. ^{[1
,2
,3
]}

Khoo, Vincent S. ^{[1
,2
,3
]}

Parker, Christopher C. ^{[1
,2
,3
]}

Woodhouse, Christopher J. ^{[2
,3
]}

Thompson, Alan ^{[2
,3
]}

Christmas, Tim ^{[2
,3
]}

Ogden, Chris ^{[2
,3
]}

Fisher, Cyril ^{[2
,3
]}

Jamieson, Charles ^{[2
,3
]}

Cooper, Colin S. ^{[1
]}

English, Dallas R. ^{[5
]}

Hopper, John L. ^{[5
]}

Neal, David E. ^{[12
,13
,14
]}

Easton, Douglas F. ^{[6
]}

机构：

[1] Inst Canc Res, Sutton SM2 5NG, Surrey, England

[2] Royal Marsden NHS Fdn Trust, Sutton SM2 5PT, Surrey, England

[3] Royal Marsden NHS Fdn Trust, London SW3 6JJ, England

[4] Canc Epidemiol Ctr, Canc Council Vic, Melbourne, Vic 3053, Australia

[5] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3053, Australia

[6] Univ Cambridge, Strangeways Lab, Canc Res UK Genet Epidemiol Unit, Cambridge CB1 8RN, England

[7] Univ Cambridge, Strangeways Lab, Dept Oncol, Cambridge CB1 8RN, England

[8] Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia

[9] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England

[10] Univ Sheffield, Acad Urol Unit, Sheffield S10 2JF, S Yorkshire, England

[11] Univ Nottingham, Sch Med, Queens Med Ctr, Nottingham NG7 2UH, England

[12] Univ Cambridge, Addenbrookes Hosp, Dept Oncol, Cambridge CB2 2QQ, England

[13] Univ Cambridge, Addenbrookes Hosp, Dept Surg, Cambridge CB2 2QQ, England

[14] Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Cambridge CB2 0RE, England

来源：

NATURE GENETICS | 2008年 / 40卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ng.90

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at <= 60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (< 0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 x 10(-8) to P = 8.7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.

引用

页码：316 / 321

页数：6

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