Dual role of the activated epidermal growth factor receptor in renal tubular cells during stress

被引:9
作者
Arany, I. [1 ,2 ]
机构
[1] Univ Arkansas Med Sci, Dept Internal Med, Little Rock, AR 72205 USA
[2] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA
关键词
D O I
10.1038/sj.ki.5002583
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The paper by Sarro et al. raises the therapeutically important possibility that activation of the epidermal growth factor receptor ( EGFR) after proximal tubule injury serves an unexpected death function and the EGFR-mediated survival signaling can be restored by identification of parallel and interacting pathways.
引用
收藏
页码:5 / 7
页数:4
相关论文
共 10 条
[1]   STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells [J].
Arany, I. ;
Megyesi, J. K. ;
Nelkin, B. D. ;
Safirstein, R. L. .
KIDNEY INTERNATIONAL, 2006, 70 (04) :669-674
[2]   CREB mediates ERK-induced survival of mouse renal tubular cells after oxidant stress [J].
Arany, I ;
Megyesi, JK ;
Reusch, JEB ;
Safirstein, RL .
KIDNEY INTERNATIONAL, 2005, 68 (04) :1573-1582
[3]   Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells [J].
Arany, I ;
Megyesi, JK ;
Kaneto, H ;
Price, PM ;
Safirstein, RL .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 287 (03) :F543-F549
[4]   Activation of ERK or inhibition of JNK ameliorates H2O2 cytotoxicity in mouse renal proximal tubule cells [J].
Arany, I ;
Megyesi, JK ;
Kaneto, H ;
Tanaka, S ;
Safirstein, RL .
KIDNEY INTERNATIONAL, 2004, 65 (04) :1231-1239
[5]   MAPK activation determines renal epithelial cell survival during oxidative injury [J].
Di Mari, JF ;
Davis, R ;
Safirstein, RL .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1999, 277 (02) :F195-F203
[6]   Opposite effects of the p52(shc)/p46(shc) and p66(shc) splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway [J].
Migliaccio, E ;
Mele, S ;
Salcini, AE ;
Pelicci, G ;
Lai, KMV ;
SupertiFurga, G ;
Pawson, T ;
DiFiore, P ;
Lanfrancone, L ;
Pelicci, PG .
EMBO JOURNAL, 1997, 16 (04) :706-716
[7]   Phosphoinositide 3-kinase inhibitors protect mouse kidney cells from cyclosporine-induced cell death [J].
Sarro, E. ;
Tornavaca, O. ;
Plana, M. ;
Meseguer, A. ;
Itarte, E. .
KIDNEY INTERNATIONAL, 2008, 73 (01) :77-85
[8]   Importance of functional EGF receptors in recovery from acute nephrotoxic injury [J].
Wang, ZF ;
Chen, JK ;
Wang, SW ;
Moeckel, G ;
Harris, RC .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (12) :3147-3154
[9]   OPPOSING EFFECTS OF ERK AND JNK-P38 MAP KINASES ON APOPTOSIS [J].
XIA, ZG ;
DICKENS, M ;
RAINGEAUD, J ;
DAVIS, RJ ;
GREENBERG, ME .
SCIENCE, 1995, 270 (5240) :1326-1331
[10]   H2O2-induced transactivation of EGF receptor requires Src and mediates ERK1/2, but not Akt, activation in renal cells [J].
Zhougang, SG ;
Schnellmann, RG .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 286 (05) :F858-F865