Advances in catalytic, enantioselective aldol addition reactions with novel Ti(IV) complexes

Global competition demands that new pharmaceuticals be prepared using cost-efficient and environmentally benign processes. The discovery and study of chemical reactions for applications in the synthesis of bioactive molecules is, therefore,of paramount importance. Advances in asymmetric catalysis should have an unquestionable impact on the development of chemotherapeutic agents. Here, the authors describe some recent developments from their laboratories in the general area of catalytic, enantioselective C-C bond-forming reactions.