Influence of erythropoietin treatment on hemoglobin A1c levels in patients with chronic renal failure on hemodialysis

被引：105

作者：

Nakao, T ^{[1
]}

Matsumoto, H ^{[1
]}

Okada, T ^{[1
]}

Han, M ^{[1
]}

Hidaka, H ^{[1
]}

Yoshino, M ^{[1
]}

Shino, T ^{[1
]}

Yamada, C ^{[1
]}

Nagaoka, Y ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Nephrol, Shinjuku Ku, Tokyo 1600023, Japan

来源：

INTERNAL MEDICINE | 1998年 / 37卷 / 10期

关键词：

renal anemia; glycemic control; hematocrit; reticulocyte;

D O I：

10.2169/internalmedicine.37.826

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied the influence of erythropoietin (EPO) treatment on hemoglobin A(1c) (HbA(1c)) levels under conditions which eliminate the effect of changes in the blood glucose concentration. HbA(1c) levels, blood glucose, hematocrit (Hct) and reticulocyte counts were serially measured every two weeks after starting or stopping EPO administration in 15 non-diabetic hemodialysis patients. EPO treatment significantly influenced HbA(1c) levels, and the more erythropoiesis fluctuated by changing the dose of EPO, the more HbA(1c) levels changed, though there were no significant changes in blood glucose levels during the study period, The changes in HbA(1c) during the 2-week period correlated inversely with both the changes in Hct during the same 2 weeks and the reticulocyte counts at that time, We concluded that the change in Hct should be kept in mind when the HbA(1c) level is evaluated in EPO-treated patients and a formula should be proposed to correct HbA(1c) levels based on the change in Hct or the reticulocyte count.

引用

页码：826 / 830

页数：5

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