Heterogeneous bacterial persisters and engineering approaches to eliminate them

被引：147

作者：

Allison, Kyle R. ^{[1
,2
]}

Brynildsen, Mark P. ^{[3
]}

Collins, James J. ^{[1
,2
,4
,5
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Howard Hughes Med Inst, Boston, MA 02215 USA

[2] Boston Univ, Ctr BioDynam, Boston, MA 02215 USA

[3] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA

[4] Boston Univ, Sch Med, Boston, MA 02118 USA

[5] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02118 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2011年 / 14卷 / 05期

关键词：

ESCHERICHIA-COLI K-12; MULTIDRUG TOLERANCE; PSEUDOMONAS-AERUGINOSA; AFFECTS LETHALITY; AFFECTS FREQUENCY; CELL-FORMATION; HIPA; GENE; INHIBITION; RESISTANCE;

D O I：

10.1016/j.mib.2011.09.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.

引用

页码：593 / 598

页数：6

共 69 条

[1] Metabolite-enabled eradication of bacterial persisters by aminoglycosides [J].

Allison, Kyle R. ;

Brynildsen, Mark P. ;

Collins, James J. .

NATURE, 2011, 473 (7346) :216-+

[2]

[Anonymous], IR J MED SCI

[3] Bacterial persistence as a phenotypic switch [J].

Balaban, NQ ;

Merrin, J ;

Chait, R ;

Kowalik, L ;

Leibler, S .

SCIENCE, 2004, 305 (5690) :1622-1625

[4] Cellular Decision Making and Biological Noise: From Microbes to Mammals [J].

Balazsi, Gabor ;

van Oudenaarden, Alexander ;

Collins, James J. .

CELL, 2011, 144 (06) :910-925

[5] Microfluidic devices for measuring gene network dynamics in single cells [J].

Bennett, Matthew R. ;

Hasty, Jeff .

NATURE REVIEWS GENETICS, 2009, 10 (09) :628-638

[6] AUTOREGULATION OF HIP, AN OPERON THAT AFFECTS LETHALITY DUE TO INHIBITION OF PEPTIDOGLYCAN OR DNA-SYNTHESIS [J].

BLACK, DS ;

IRWIN, B ;

MOYED, HS .

JOURNAL OF BACTERIOLOGY, 1994, 176 (13) :4081-4091

[7] STRUCTURE AND ORGANIZATION OF HIP, AN OPERON THAT AFFECTS LETHALITY DUE TO INHIBITION OF PEPTIDOGLYCAN OR DNA-SYNTHESIS [J].

BLACK, DS ;

KELLY, AJ ;

MARDIS, MJ ;

MOYED, HS .

JOURNAL OF BACTERIOLOGY, 1991, 173 (18) :5732-5739

[8] Structure of the Escherichia coli Antitoxin MqsA (YgiT/b3021) Bound to Its Gene Promoter Reveals Extensive Domain Rearrangements and the Specificity of Transcriptional Regulation [J].

Brown, Breann L. ;

Wood, Thomas K. ;

Peti, Wolfgang ;

Page, Rebecca .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (03) :2285-2296

[9] Three Dimensional Structure of the MqsR: MqsA Complex: A Novel TA Pair Comprised of a Toxin Homologous to RelE and an Antitoxin with Unique Properties [J].

Brown, Breann L. ;

Grigoriu, Simina ;

Kim, Younghoon ;

Arruda, Jennifer M. ;

Davenport, Andrew ;

Wood, Thomas K. ;

Peti, Wolfgang ;

Page, Rebecca .

PLOS PATHOGENS, 2009, 5 (12)

[10] Kinase activity of overexpressed HipA is required for growth arrest and multidrug tolerance in Escherichia coli [J].

Correia, Frederick F. ;

D'Onofrio, Anthony ;

Rejtar, Tomas ;

Li, Lingyun ;

Karger, Barry L. ;

Makarova, Kira ;

Koonin, Eugene V. ;

Lewis, Kim .

JOURNAL OF BACTERIOLOGY, 2006, 188 (24) :8360-8367

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