Efficient synthesis of highly substituted indolizinones via iodocyclization and 1,2-shift

被引：40

作者：

Choi, Jihyun ^{[1
]}

Lee, Ge Hyeong ^{[1
]}

Kim, Ikyon ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Ctr Med Chem, Taejon 305600, South Korea

来源：

SYNLETT | 2008年 / 08期

关键词：

indolizinones; iodine; cyclizations; rearrangements; 1,2-migration;

D O I：

10.1055/s-2008-1072721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 5-endo-dig iodocyclization of propargylic alcohols followed by a 1,2-shift provided rapid access to 2-iodoindolizinones, while the 5-endo-trig iodocyclization of allylic alcohols and subsequent dehydroiodination and 1,2-shift led to indolizinones. A number of highly substituted indolizinones were constructed under these mild reaction conditions.

引用

页码：1243 / 1249

页数：7

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