Mechanisms of disease: the role of stem cells in the biology and treatment of gliomas

被引：40

作者：

Dietrich, Joerg

Imitola, Jaime ^{[1
,2
]}

Kesari, Santosh

机构：

[1] Harvard Univ, Sch Med, Harvard Stem Cell Inst, Boston, MA USA

[2] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

来源：

NATURE CLINICAL PRACTICE ONCOLOGY | 2008年 / 5卷 / 07期

关键词：

brain tumor stem cells; cancer stem cells; gliomas; neural stem cells; progenitor cells;

D O I：

10.1038/ncponc1132

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The study of neural stem cell and progenitor cell biology has improved our understanding of the biology of brain tumors in a developmental context. Recent work has demonstrated that brain tumors may harbor small subpopulations of cells that share characteristics of neural stem cells. There is still an ongoing debate about the specific role of these stem-like cells in cancer initiation, development and progression. Nonetheless, the concept of cancer stem cells has offered a new paradigm to understand tumor biology and resistance to current treatment modalities. Molecular aberrations in these cancer stem cells might be crucial targets for therapeutic intervention, with the hope of achieving more durable clinical responses. Recent studies have demonstrated that endogenous and transplanted neural stem cells and progenitor cells show a marked tropism to brain tumors. Although the mechanisms that govern these processes are poorly understood, the use of neural stem cells and progenitor cells as delivery vehicles for molecules toxic to tumors offers a promising experimental treatment strategy. This Review summarizes recent advances in the basic understanding of neural stem cell and cancer stem cell biology and the progress towards translating these novel concepts into the clinic.

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收藏

页码：393 / 404

页数：12

相关论文

共 103 条

[1] Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].

Aboody, KS ;

Brown, A ;

Rainov, NG ;

Bower, KA ;

Liu, SX ;

Yang, W ;

Small, JE ;

Herrlinger, U ;

Ourednik, V ;

Black, PM ;

Breakefield, XO ;

Snyder, EY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851

[2] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[3] AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].

ALTMAN, J ;

DAS, GD .

JOURNAL OF COMPARATIVE NEUROLOGY, 1965, 124 (03) :319-&

[4] For the long run: Maintaining germinal niches in the adult brain [J].

Alvarez-Buylla, A ;

Lim, DA .

NEURON, 2004, 41 (05) :683-686

[5] Isolation of multipotent neural precursors residing in the cortex of the adult human brain [J].

Arsenijevic, Y ;

Villemure, JG ;

Brunet, JF ;

Bloch, JJ ;

Déglon, N ;

Kostic, C ;

Zurn, A ;

Aebischer, P .

EXPERIMENTAL NEUROLOGY, 2001, 170 (01) :48-62

[6] Epidermal growth factor receptor and Ink4a/Arf:: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis [J].

Bachoo, RM ;

Maher, EA ;

Ligon, KL ;

Sharpless, NE ;

Chan, SS ;

You, MJJ ;

Tang, Y ;

DeFrances, J ;

Stover, E ;

Weissleder, R ;

Rowitch, DH ;

Louis, DN ;

DePinho, RA .

CANCER CELL, 2002, 1 (03) :269-277

[7] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[8] Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor [J].

Bao, Shideng ;

Wu, Qiulian ;

Sathornsumetee, Sith ;

Hao, Yueling ;

Li, Zhizhong ;

Hjelmeland, Anita B. ;

Shi, Oing ;

McLendon, Roger E. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

CANCER RESEARCH, 2006, 66 (16) :7843-7848

[9] Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells transformed with c-myc and H-ras form high-grade glioma after stereotactic injection into the rat brain [J].

Barnett, SC ;

Robertson, L ;

Graham, D ;

Allan, D ;

Rampling, R .

CARCINOGENESIS, 1998, 19 (09) :1529-1537

[10] Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy [J].

Barresi, V ;

Belluardo, N ;

Sipione, S ;

Mudó, G ;

Cattaneo, E ;

Condorelli, DF .

CANCER GENE THERAPY, 2003, 10 (05) :396-402

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