Ghrelin: A new peptide regulating growth hormone release and food intake

被引：62

作者：

De Vriese, Carine ^{[1
]}

Delporte, Christine ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Fac Med, Lab Biol Chem & Nutr, B-1070 Brussels, Belgium

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2008年 / 40卷 / 08期

关键词：

ghrelin; metabolism; appetite regulation; energy homeostasis;

D O I：

10.1016/j.biocel.2007.04.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Ghrelin, identified as an endogenous ligand for the growth hormone secretagogue receptor, is a 28 amino, acid peptide hormone possessing an unusual octanoyl group on the serine in position 3, crucial for its biological activity. Ghrelin is predominantly produced by the stomach but also by many other tissues such as pituitary, hypothalamus, duodenum, jejunum, ileum, colon, lung, heart, pancreas, kidney, and testis. In addition to stimulation of GH release, ghrelin stimulates appetite and food intake, enhancing fat mass deposition and weight gain. Besides these main actions, ghrelin regulates gastric motility and acid secretion, exerts cardiovascular and anti-inflammatory effects, modulates cell proliferation and influences endocrine and exocrine pancreatic secretion, as well as glucose and lipid metabolism. Therefore, ghrelin agonists and antagonists might be valuable for some clinical aspects. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1420 / 1424

页数：5

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