Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes mellitus

被引：45

作者：

Masaki, Takayuki ^{[1
]}

Anan, Futoshi ^{[2
]}

Shimomura, Tsuyoshi ^{[3
]}

Fujiki, Minoru ^{[3
]}

Saikawa, Tetsunori ^{[1
]}

Yoshimatsu, Hironobu ^{[1
]}

机构：

[1] Oita Univ Oita, Dept Internal Med, Oita, Japan

[2] Oita Red Cross Hosp, Dept Cardiol, Oita, Japan

[3] Oita Univ Oita, Sch Med, Dept Neurosurg, Oita, Japan

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2012年 / 61卷 / 08期

关键词：

VOXEL-BASED MORPHOMETRY; ALZHEIMERS-DISEASE; OBESE MICE; TNF-ALPHA; DEMENTIA; PLASMA; HEALTH; RISK;

D O I：

10.1016/j.metabol.2012.01.016

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Type 2 diabetes mellitus (DM) is associated with cognitive dysfunction and hippocampus volume. The aim of the present study was to test the hypothesis that the level of the adipocytokine adiponectin correlates with hippocampus volume and insulin resistance in patients with type 2 DM. A total of 45 patients with type 2 DM were divided into two groups: a low adiponectin group and a normal adiponectin group. Hippocampus volume was measured by computer-assisted analysis using a magnetic resonance imaging (MRI) voxel-based specific regional analysis system developed for the study of Alzheimer's disease as the end point for assessment of hippocampus volume. Mean hippocampus volume was lower in the low adiponectin group than in the normal adiponectin group (P < .0001). Fasting serum concentrations of glucose (P < .05) and insulin (P < .0001), and homeostasis model assessment index (P < .0001), were all higher in the low adiponectin group than in the normal adiponectin group. Multiple regression analysis showed that hippocampus volume independently predicted serum adiponectin level. These results suggest that circulating levels of adiponectin are related to hippocampus volume in patients with type 2 DM. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1197 / 1200

页数：4

共 20 条

[1]

Abdominal visceral fat accumulation is associated with hippocampus volume in non-dementia patients with type 2 diabetes mellitus [J].