Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats

被引：63

作者：

Carasso, BS

Bakshi, VP

Geyer, MA

机构：

[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

来源：

NEUROPHARMACOLOGY | 1998年 / 37卷 / 03期

关键词：

startle; norepinephrine; cirazoline; antipsychotic; schizophrenia; sensorimotor gating;

D O I：

10.1016/S0028-3908(98)00051-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of the alpha-1 adrenoceptor in prepulse inhibition (PPI) was evaluated in rats. The alpha-1 adrenergic agonist cirazoline disrupted PPI; this effect was reversed by the alpha-1 adrenergic antagonist prazosin or the atypical antipsychotic quetiapine. Alpha-1 adrenoceptors may thus be involved in the regulation of PPI and in the psychotherapeutic actions of certain antipsychotics. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：401 / 404

页数：4

共 12 条

[1] SPINAL MODULATION OF THE ACOUSTIC STARTLE RESPONSE - THE ROLE OF NOREPINEPHRINE, SEROTONIN AND DOPAMINE [J].