Ly-6C is expressed in brain vessels endothelial cells but not in microglia of the mouse

被引：10

作者：

Alliot, F

Rutin, J

Pessac, B

机构：

[1] Fac Med Broussais Hotel Dieu, CNRS UPR 9035, F-75270 Paris 06, France

[2] Fac Med Broussais Hotel Dieu, ER 1783, F-75270 Paris, France

来源：

NEUROSCIENCE LETTERS | 1998年 / 251卷 / 01期

关键词：

mouse; central nervous system; microglia; vessels; endothelium;

D O I：

10.1016/S0304-3940(98)00473-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The Ly-6C antigen is expressed in various cell types of the immune system, including macrophages. Using the monoclonal antibody ER-MP20 which specifically recognises Ly-6C, we have investigated whether brain parenchymatous microglia express Ly-6C in vivo as well as in vitro, in brain sections from developing and adult C57/Bl mice, all vessels were strongly immunolabelled. Electron microscopic immunohistochemistry showed that the endothelial cells are the cell type expressing Ly-6C. In contrast, we never observed immunoreactivity on microglia; however, microglial cells proliferating in vitro were strongly ER-MP20 positive. These data show that Ly-6C is not a marker for microglia in vivo. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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页码：37 / 40

页数：4

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