Cerebro-muscular and cerebro-cerebral coherence in patients with pre- and perinatally acquired unilateral brain lesions

被引:26
作者
Belardinelli, P.
Clancetta, L.
Staudt, M.
Pizzella, V.
Londei, A.
Birbaumer, N.
Romani, G. L.
Braun, C.
机构
[1] G D Annunzio Univ Fdn, Inst Adv Biomed Technol, ITAB, I-66013 Chieti, Italy
[2] Univ G dAnnunzio, Dept Clin Sci & Biomed Imaging, Chieti, Italy
[3] Univ Tubingen, MEG Ctr, Tubingen, Germany
[4] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany
[5] Univ Roma La Sapienza, Interuniv Ctr REs Cognit Proc Nat & Atrificial Sy, ECONA, Rome, Italy
关键词
MEG; coherence; brain lesions; oscillations; synchronization;
D O I
10.1016/j.neuroimage.2007.05.053
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cerebral networks involved in motor control were analyzed in four young hemi-paretic patients (21-25 years) with pre- and perinatally acquired brain lesions (3 with left periventricular brain lesions, I with left schizencephaly) by means of MEG source coherence analysis. Previous TMS and fMRI studies on the same patients had investigated their residual ability to move the paretic hand by means of a reorganized primary motor cortex (MI) representation in the contralesional hemisphere. The purpose of this study is to identify the effects of such a cerebral reorganization and the related dynamic aspects which allow the patients to move the paretic arm. Patients underwent a pinch grip task (1-N isometric contraction) using their paretic and non-paretic hands in alternation. MEG signals were recorded using a whole-head 151-channel magnetoencephalograph. EMG was simultaneously recorded as a reference for coherence calculations. 3D coherence mapping was performed in the beta frequency range (14-30 Hz). This approach confirmed the relocation of motor functions from the lesioned (left) to the contralesional (right) hemisphere. In case of left, non-paretic pinch grip, coherent activity originated from contralateral (right) MI exclusively. In the case of right (paretic) grip, coherent activity in ipsilateral M I as well as significant coherence of ipsilateral cerebellum with both muscle activity and MI itself was detected in 3 out of 4 subjects. As expected, the patient with no cerebellar involvement during paretic hand contraction showed the worst motor performance in the grip task.
引用
收藏
页码:1301 / 1314
页数:14
相关论文
共 55 条
[1]   Oscillatory activity in forelimb muscles of behaving monkeys evoked by micro stimulation in the cerebellar nuclei [J].
Aumann, TD ;
Fetz, EE .
NEUROSCIENCE LETTERS, 2004, 361 (1-3) :106-110
[2]   Localizing complex neural circuits with MEG data [J].
Belardinelli P. ;
Ciancetta L. ;
Pizzella V. ;
Del Gratta C. ;
Romani G.L. .
Cognitive Processing, 2006, 7 (1) :53-59
[3]   Introduction to the bootstrap world [J].
Boos, DD .
STATISTICAL SCIENCE, 2003, 18 (02) :168-174
[4]   PATTERNS OF CENTRAL MOTOR REORGANIZATION IN HEMIPLEGIC CEREBRAL-PALSY [J].
CARR, LJ ;
HARRISON, LM ;
EVANS, AL ;
STEPHENS, JA .
BRAIN, 1993, 116 :1223-1247
[5]  
CHEYNE D, 2004, P 14 INT C BIOM BOST
[6]  
Cimponeriu L, 2004, PHYS REV E, V70, DOI 10.1103/PhysRevE.70.046213
[7]   Classification of movement intention by spatially filtered electromagnetic inverse solutions [J].
Congedo, M. ;
Lotte, F. ;
Lecuyer, A. .
PHYSICS IN MEDICINE AND BIOLOGY, 2006, 51 (08) :1971-1989
[8]  
CONGEDO M, 2004, ZERO LOCALIZATION ER
[9]   Synchronization between motor cortex and spinal motoneuronal pool during the performance of a maintained motor task in man [J].
Conway, BA ;
Halliday, DM ;
Farmer, SF ;
Shahani, U ;
Maas, P ;
Weir, AI ;
Rosenberg, JR .
JOURNAL OF PHYSIOLOGY-LONDON, 1995, 489 (03) :917-924
[10]   Local field potential oscillations in primate cerebellar cortex: Synchronization with cerebral cortex during active and passive expectancy [J].
Courtemanche, R ;
Lamarre, Y .
JOURNAL OF NEUROPHYSIOLOGY, 2005, 93 (04) :2039-2052