Selective detection of saxitoxin over tetrodotoxin using acridinylmethyl crown ether chemosensor

被引：27

作者：

Gawley, RE ^{[1
]}

Shanmugasundaram, M

Thorne, JB

Tarkka, RM

机构：

[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA

[2] Univ Cent Arkansas, Conway, AR 72035 USA

来源：

TOXICON | 2005年 / 45卷 / 06期

关键词：

saxitoxin; PSP; tetrodotoxin; fluorescence sensor;

D O I：

10.1016/j.toxicon.2005.01.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

At pH 7.1, saxitoxin decomposes to produce a trace impurity that can interfere with fluorescence sensing when using irradiation wavelengths near 325 nm. The fluorophore acridine is found to be a suitable component of arylmethyl crown ether chemosensors for the fluorescent detection of saxitoxin. These sensors are selective for the detection of saxitoxin over tetrodotoxin. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：783 / 787

页数：5

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