The mutagenic potentials of tap water samples in Shanghai

被引:48
作者
Shen, L
Wu, JY
Lin, GF
Shen, JH
Westendorf, J
Huehnerfuss, H
机构
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Shanghai 200025, Peoples R China
[2] Univ Hamburg, Sch Med, Inst Toxicol & Environm Med, D-22527 Hamburg, Germany
[3] Univ Hamburg, Inst Organ Chem, D-20146 Hamburg, Germany
关键词
Ames test; Ara test; GC-MS; mutagenicity; SOS/umu test; Taihu Lake basin; tap water; Yangtze River;
D O I
10.1016/S0045-6535(03)00504-6
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The tap water samples were collected from the users' ends in several areas of Shanghai, which is located in Taihu Lake basin, Eastern China. Source water samples were also collected from two municipal source water facilities at the same time. Samples were assayed by three different short-term mutagenicity test systems: Salmonella/microsome assay (Ames test), the Arabinose resistance test (Ara test) and the SOS/umu test. The data showed that two source water samples did not display direct mutagenic potentials. Two tap water samples from city north, which were directly from Yangtze River, were also not mutagenic. Water samples from city south and middle which used source water originating from Taihu Lake were proved to be contaminated with mutagenic potentials by three different assay techniques. The boiled water displayed an even stronger mutagenic potential compared to its original tap water. The molecular mechanism of mutagenicity was associated with a reading frame-shifting potential. GC-MS analysis of tap water extracts from city middle and corresponding source water was compared. Qualitatively similar spectra were observed except for the peaks of three chlorinated aromatic hydrocarbon compounds, which existed only in the tap water. Since the water source has been polluted, raw water was heavily chlorinated in order to sterilize. More toxic compounds, including mutagens, might form during the multi-chlorination. Caution about the possibility of elevated cancer risks in the population that consumes heavily chlorinated water should be kept in mind. A cohort study in the residents of Shanghai is required. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1641 / 1646
页数:6
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