Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties

被引：29

作者：

Grogna, Mathurin ^{[1
]}

Cloots, Rudi ^{[2
]}

Luxen, Andre ^{[3
]}

Jerome, Christine ^{[1
]}

Passirani, Catherine ^{[4
]}

Lautram, Nolwenn ^{[4
]}

Desreux, Jean-F.

Detrembleur, Christophe ^{[1
]}

机构：

[1] Univ Liege, Ctr Educ & Res Macromol CERM, B-4000 Liege, Belgium

[2] Univ Liege, Lab Chim Inorgan Struct, B-4000 Liege, Belgium

[3] Univ Liege, Cyclotron Res Ctr, B-4000 Liege, Belgium

[4] INSERM, U646, F-49000 Angers, France

来源：

POLYMER CHEMISTRY | 2010年 / 1卷 / 09期

关键词：

PROTON RELAXATION ENHANCEMENT; GD3+-DIETHYLENETRIAMINEPENTAACETIC ACID; HIGH-RELAXIVITY; GD-DTPA; NANOPARTICLES; CARRIERS; DEXTRAN; COPOLYMERS; INTERPLAY; ALBUMIN;

D O I：

10.1039/c0py00117a

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO-b-PCL) in water. As evidenced by relaxometry measurements and the hemolytic CH50 test, the new contrast agents are of interest as MRI blood pool agents.

引用

页码：1485 / 1490

页数：6

共 45 条

[1] High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI [J].

Accardo, Antonella ;

Tesauro, Diego ;

Morelli, Giancarlo ;

Gianolio, Eliana ;

Aime, Silvio ;

Vaccaro, Mauro ;

Mangiapia, Gaetano ;

Paduano, Luigi ;

Schillen, Karin .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2007, 12 (02) :267-276

[2]

André JP, 1999, CHEM-EUR J, V5, P2977, DOI 10.1002/(SICI)1521-3765(19991001)5:10<2977::AID-CHEM2977>3.0.CO

[3]

2-T

[4] PEO coated magnetic nanoparticles for biomedical application [J].

Aqil, A. ;

Vasseur, S. ;

Duguet, E. ;

Passirani, C. ;

Benoit, J. P. ;

Roch, A. ;

Muller, R. ;

Jerome, R. ;

Jerome, C. .

EUROPEAN POLYMER JOURNAL, 2008, 44 (10) :3191-3199

[5] Long-circulating liposomal contrast agents for magnetic resonance imaging [J].

Ayyagari, AL ;

Zhang, XD ;

Ghaghada, KB ;

Annapragada, A ;

Hu, XP ;

Bellamkonda, RV .

MAGNETIC RESONANCE IN MEDICINE, 2006, 55 (05) :1023-1029

[6]

Bryant LH, 1999, JMRI-J MAGN RESON IM, V9, P348, DOI 10.1002/(SICI)1522-2586(199902)9:2<348::AID-JMRI30>3.0.CO

[7]

2-J

[8] Strategies for increasing the sensitivity of gadolinium based MRI contrast agents [J].

Caravan, Peter .

CHEMICAL SOCIETY REVIEWS, 2006, 35 (06) :512-523

[9]

Clarkson RB, 2002, TOP CURR CHEM, V221, P201

[10] Soluble Polymer Carriers for the Treatment of Cancer: The Importance of Molecular Architecture [J].

Fox, Megan E. ;

Szoka, Francis C. ;

Frechet, Jean M. J. .

ACCOUNTS OF CHEMICAL RESEARCH, 2009, 42 (08) :1141-1151

← 1 2 3 4 5 →