Calpain inhibitors, a treatment for Alzheimer's disease - Position paper

被引：59

作者：

Battaglia, F ^{[1
]}

Trinchese, F ^{[1
]}

Liu, SM ^{[1
]}

Walter, S ^{[1
]}

Nixon, RA ^{[1
]}

Arancio, O ^{[1
]}

机构：

[1] NYU, Sch Med, Nathan S Kline Inst Psychiat Res, Dept Psychiat, Orangeburg, NY 10962 USA

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2003年 / 20卷 / 03期

关键词：

Alzheimer's disease; calpain; transgenic models; hippocampus; amyloid precursor protein; presenilin; 1;

D O I：

10.1385/JMN:20:3:357

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calpains modulate processes that govern the function and metabolism of proteins key to the pathogenesis of Alzheimer's disease, including tau and amyloid precursor protein. Because activation of the calpain system might contribute to the impairment of synaptic transmission in Alzheimer's disease, we are currently testing the hypotheses that a treatment with calpain inhibitors might restore normal cognition and synaptic transmission in a transgenic model of Alzheimer's disease, the APP (K670N:M671L)/PS1(M146L) mouse. Findings derived from these studies will provide a novel approach to cognitive enhancement in Alzheimer's disease.

引用

页码：357 / 362

页数：6

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