Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-l3.4 by an intragenic polymorphic marker

被引：4

作者：

Bellingham, J

Gregory-Evans, K

Gregory-Evans, CY

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Mol Genet, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Acad Unit Ophthalmol, London SW7 2AZ, England

来源：

ANNALS OF HUMAN GENETICS | 1998年 / 62卷

基金：

英国惠康基金;

关键词：

D O I：

10.1046/j.1469-1809.1998.6230231.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have identified a highly polymorphic intragenic marker composed of two dinucleotide repeats in an intron of the human interferon regulatory factor (IRF3) gene. This polymorphic marker has allowed us to map IRF3 to the boundary of 19q13.3-13.4 between the polymorphic markers D19S604 and D19S206 close to KLK1. An intron is present in a homologous position in the mouse Irf3 gene, but lacks the dinucleotide repeats present in the human intron. Syntenic conservation between this region of 19q13.3-13.4 maps Irf3 to either mouse chromosome 7 or 17.

引用

页码：231 / 234

页数：4

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