Occurrence of cancer in a cohort of 183 persons with constitutional chromosome 7 abnormalities

被引：19

作者：

Hasle, H

Olsen, JH

Hansen, J

Friedrich, U

Tommerup, N

机构：

[1] Aarhus Univ Hosp, Dept Pediat, DK-8000 Aarhus, Denmark

[2] Danish Canc Soc, Div Canc Epidemiol, Copenhagen, Denmark

[3] Aarhus Psychiat Hosp, Danish Cytogenet Register, Risskov, Denmark

[4] Aarhus Univ, Inst Human Genet, DK-8000 Aarhus, Denmark

[5] Univ Copenhagen, Panum Inst, Dept Med Genet, DK-2200 Copenhagen, Denmark

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 105卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(98)00007-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic abnormalities in human malignancies frequently involve chromosome 7. The existence of several tumor suppressor genes on the long ann of chromosome 7 has been suggested in both epithelial and hematologic malignancies. From the Danish Cytogenetic Register, we identified 183 persons with constitutional abnormalities involving chromosome 7, including 16 patients with Williams syndrome. By linkage to the Danish Cancer Registry, we found five persons with cancer, including one thyroid carcinoma, three carcinomas of the digestive tract, and one malignant melanoma. There were no cases of leukemia. The overall risk of developing cancer was not increased. (C) Elsevier Science Inc., 1998.

引用

页码：39 / 42

页数：4

共 29 条

[1] WILMS TUMOR, MALFORMATIVE SYNDROME, MENTAL-RETARDATION AND DENOVO CONSTITUTIONAL TRANSLOCATION, T(7-13)(Q36-Q13) [J].