Examining the hygiene hypothesis: the trial of infant probiotic supplementation

被引：25

作者：

Cabana, Michael D.

McKean, Michelle

Wong, Angela R.

Chao, Cewin

Caughey, Aaron B.

机构：

[1] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Obstet & Gynecol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Inst Hlth Policy Studies, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Clin & Translat Sci Inst, San Francisco, CA 94143 USA

[6] Kaiser Permanente, Dept Pediat, San Francisco, CA USA

来源：

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY | 2007年 / 21卷

关键词：

randomised controlled trial; probiotics; asthma; hygiene hypothesis;

D O I：

10.1111/j.1365-3016.2007.00881.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The hygiene hypothesis suggests that the absence of infectious exposure at a critical point in immune system development leads to a greater risk for the later development of atopic disease. As a result, it may be possible to devise strategies that can block the onset of atopic diseases such as asthma. This paper outlines the rationale, background and design for the Trial of Infant Probiotic Supplementation study, which is designed to test the effectiveness of a daily infant probiotic supplement in the first 6 months of life in preventing the development of early markers of asthma.

引用

页码：23 / 28

页数：6

共 33 条

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