Statins and renal function in patients with diabetes mellitus

被引：76

作者：

Athyros, VG

Papageorgiou, AA

Elisaf, M

Mikhailidis, DP

机构：

[1] Aristotle Univ Thessaloniki, Hippocrat Hosp, Propedeut Dept Internal Med 2, Atherosclerosis Unit, GR-54006 Thessaloniki, Greece

[2] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece

[3] UCL Royal Free & Univ Coll, Royal Free Hosp, Sch Med, Dept Clin Biochem,Vasc Dis Prevent Clin, London, England

来源：

CURRENT MEDICAL RESEARCH AND OPINION | 2003年 / 19卷 / 07期

关键词：

creatinine; diabetes mellitus; lipids; renal function; statins;

D O I：

10.1185/030079903125002315

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipids may adversely affect renal function. The recently published MRC/BHF Heart Protection Study (HPS) subgroup analysis showed that simvastatin significantly reduced the fall in glomerular filtration rate in high-risk patients with and without diabetes mellitus. These findings are in line with those of smaller earlier studies, including the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study. Lipid lowering trials need to consider that changes in renal function may occur. Renal and ischaemic heart disease may progress in parallel and statins may be beneficial to both organs.

引用

页码：615 / 617

页数：3

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