Ruthenium catalysed redox transformation of cinnamaldehyde to 3-phenylpropionic acid and methyl ester.

被引：22

作者：

de Vries, JG ^{[1
]}

Roelfes, G ^{[1
]}

Green, R ^{[1
]}

机构：

[1] DSM Res, Dept Fine Chem, NL-6160 MD Geleen, Netherlands

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(98)01827-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Phenylpropionic acid (2) is an intermediate for the anti-aids drug Indinavir. The one step conversion of cinnamaldehyde (4) into 2 was attempted using homogeneous ruthenium catalysts. Use of [H2Ru(Ph3P)(4)] induced mainly decarbonylation of 4 to give styrene. Use of RuCl3/PCy3 gave a mixture of 2 and cinnamic acid (3). Performing the same reaction in methanol, instead of water/dimethoxyethane mixtures afforded methyl 3-phenylpropionate in 70% yield. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8329 / 8332

页数：4

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