Novel 4D numerical representation of DNA sequences

被引：70

作者：

Chi, R ^{[1
]}

Ding, KQ ^{[1
]}

机构：

[1] Chinese Acad Sci, Dept Appl Math, Grad Sch, Beijing 100049, Peoples R China

来源：

CHEMICAL PHYSICS LETTERS | 2005年 / 407卷 / 1-3期

关键词：

D O I：

10.1016/j.cplett.2005.03.056

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 [物理化学]; 081704 [应用化学];

摘要：

We introduce a 4D numerical representation of DNA sequences and its application. Advantages and limitations are discussed. The method is illustrated by constructing sequence invariants on the coding sequence of the first exon of human beta-globin gene. As application, we use the way, which is based on the construction of a vector whose components are the normalized leading eigen-values of the L/L matrices associated with DNA sequences, to examine the similarities/dissimilarities among the coding sequences of the first exon of P-globin gene of 11 different species. And state the easy way in counting the numbers of nucleotide substitutions by coordinates. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：63 / 67

页数：5

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