Phototriggered drug release from functionalized oligonucleotides by a molecular beacon strategy

被引:49
作者
Okamoto, A
Tanabe, K
Inasaki, T
Saito, I [1 ]
机构
[1] Kyoto Univ, Fac Engn, Dept Synthet Chem & Biol Chem, Kyoto 6068501, Japan
[2] Japan Sci & Technol Corp, SORST, Kyoto 6068501, Japan
关键词
drug delivery; molecular devices; oligonucleoticles; photolysis;
D O I
10.1002/anie.200250832
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
More than just a light switch: A phototriggered molecule-releasing system controlled through intramolecular triplet quenching by using a molecular beacon strategy with photoactive probe oligodeoxynucleotides (ODNs) has been developed (see picture).
引用
收藏
页码:2502 / 2504
页数:3
相关论文
共 12 条
[1]   New phototriggers:: Extending the p-hydroxyphenacyl π-π* absorption range [J].
Conrad, PG ;
Givens, RS ;
Weber, JFW ;
Kandler, K .
ORGANIC LETTERS, 2000, 2 (11) :1545-1547
[2]   New photoactivated protecting groups .7. p-Hydroxyphenacyl: A phototrigger for excitatory amino acids and peptides [J].
Givens, RS ;
Jung, A ;
Park, CH ;
Weber, J ;
Bartlett, W .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (35) :8369-8370
[3]   New phototriggers 9:: p-hydroxyphenacyl as a C-terminal photoremovable protecting group for oligopeptides [J].
Givens, RS ;
Weber, JFW ;
Conrad, PG ;
Orosz, G ;
Donahue, SL ;
Thayer, SA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (12) :2687-2697
[5]   A labeling, detection, and purification system based on 4-hydroxyazobenzene-2-carboxylic acid: An extension of the avidin-biotin system [J].
Hofstetter, H ;
Morpurgo, M ;
Hofstetter, O ;
Bayer, EA ;
Wilchek, M .
ANALYTICAL BIOCHEMISTRY, 2000, 284 (02) :354-366
[6]   Nucleic acid-triggered catalytic drug release [J].
Ma, ZC ;
Taylor, JS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11159-11163
[7]   Nucleic acid triggered catalytic drug and probe release: A new concept for the design of chemotherapeutic and diagnostic agents [J].
Ma, ZC ;
Taylor, JS .
BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (09) :2501-2510
[8]   Molecular beacon sequence analysis for detecting drug resistance in Mycobacterium tuberculosis [J].
Piatek, AS ;
Tyagi, S ;
Pol, AC ;
Telenti, A ;
Miller, LP ;
Kramer, FR ;
Alland, D .
NATURE BIOTECHNOLOGY, 1998, 16 (04) :359-363
[9]   PHENACYL PHOTOSENSITIVE BLOCKING GROUPS [J].
SHEEHAN, JC ;
UMEZAWA, K .
JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (21) :3771-3774
[10]   Molecular beacons: Probes that fluoresce upon hybridization [J].
Tyagi, S ;
Kramer, FR .
NATURE BIOTECHNOLOGY, 1996, 14 (03) :303-308