The many substrates and functions of ATM

被引：635

作者：

Kastan, MB ^{[1
]}

Lim, DS ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2000年 / 1卷 / 03期

关键词：

D O I：

10.1038/35043058

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

As its name suggests, the ATM - 'ataxia-telangiectasia, mutated' - gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.

引用

页码：179 / 186

页数：8

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