Immune cells as anti-cancer therapeutic targets and tools

被引：21

作者：

Johansson, Magnus

Tan, Tingting

de Visser, Karin E.

Coussens, Lisa M.

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA

[3] Netherlands Canc Inst, Dept Mol Biol, NL-1066 CX Amsterdam, Netherlands

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2007年 / 101卷 / 04期

关键词：

cancer; immune cells; inflammation; innate; adative; NATURAL-KILLER-CELLS; MAST-CELLS; NK CELLS; T-CELLS; MACROPHAGE INFILTRATION; CHRONIC INFLAMMATION; DENDRITIC CELLS; CANCER; CARCINOMA; ANGIOGENESIS;

D O I：

10.1002/jcb.21230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chronic inflammation is a contributing factor to overall cancer risk as well as cancer promotion and progression; however, pathways regulating onset of cancer-promoting inflammatory responses are still poorly understood. Clinical data suggest that deficient anti-tumor cell-mediated immunity, in combination with enhanced pro-tumor humoral and/or innate immunity (inflammation), are significant factors influencing malignant outcome. Here, we discuss therapeutic implications from clinical data and experimental studies using de novo immune-competent mouse models of cancer development that together are revealing molecular and cellular mechanisms underlying interactions between immune cells and evolving neoplastic cells that regulate cancer outcome. Understanding the functionally significant links between adaptive and innate immunity that regulate cancer development will open new therapeutic opportunities to manipulate aspects of immunobiology and minimize lethal effects of cancer development.

引用

页码：918 / 926

页数：9

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