Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains

被引：43

作者：

Mogi, M

Togari, A

Kondo, T

Mizuno, Y

Kogure, O

Kuno, S

Ichinose, H

Nagatsu, T ^{[1
]}

机构：

[1] Fujita Hlth Univ, Inst Comprehens Med Sci, Toyoake, Aichi 4701192, Japan

[2] Aichi Gakuin Univ, Sch Dent, Dept Pharmacol, Nagoya, Aichi 4648650, Japan

[3] Juntendo Univ, Sch Med, Dept Neurol, Tokyo 1138432, Japan

[4] Natl Utano Hosp, Dept Neurol, Kyoto 6168255, Japan

[5] Natl Utano Hosp, Clin Res Ctr, Kyoto 6168255, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 300卷 / 03期

关键词：

glial cell line-derived neurotrophic factor; Parkinson's disease; brain;

D O I：

10.1016/S0304-3940(01)01577-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glial cell line-derived neurotrophic factor (GDNF) was measured for the first time in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, and frontal cortex) from control and parkinsonian patients by highly sensitive sandwich enzyme-linked immunosorbent assay. In both groups, the levels of GDNF in the various brain regions were lower (pg/mg protein) than those of brain-derived growth factor (ng/mg order), and were significantly higher in the nigro-striatal dopaminergic regions (substantia nigra, caudate nucleus, putamen) than in the cerebellum and frontal cortex (P < 0.05). However, the content of GDNF in the dopaminergic regions showed no significant difference between parkinsonian and control patients. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：179 / 181

页数：3

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