Bone marrow-derived stem cells and 'plasticity'

被引:45
作者
Hüttmann, A
Li, CL
Dührsen, U
机构
[1] Univ Essen Gesamthsch Klinikum, Zentrum Innere Med, Klin Hamatol, D-45157 Essen, Germany
[2] Acad Sinica, Inst Zool, Taipei 11529, Taiwan
关键词
stem cell plasticity; transdifferentiation; hematopoiesis; bone marrow;
D O I
10.1007/s00277-003-0713-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Studies describing plasticity of somatic stem cells have become a focus of interest because clinical applications in the treatment of degenerative diseases would be at hand. In particular, bone marrow-derived cells and their potential to contribute to skeletal and cardiac muscle, liver, neurons and epithelium have recently been studied extensively. Nevertheless, results of these studies have not always been consistent with each other, and yet it remains to be resolved whether plasticity of adult stem cells truly exists. This review will discuss the role of bone marrow-derived stem cells in the field of experimental and clinical plasticity studies. Observations compatible with the concept of stem cell plasticity will be weighed against limitations of the experimental systems employed.
引用
收藏
页码:599 / 604
页数:6
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