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Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus

被引：49
作者：
Jeon, Gye Sun
Park, Sung Kyung
Park, Sang Wook
Kim, Dong Woon
Chung, Chun Kee
Cho, Sa Sun
机构：
[1] Seoul Natl Univ, Coll Med, Dept Anat, Seoul 110799, South Korea
[2] Chungnam Natl Univ, Coll Med, Dept Anat, Taejon, South Korea
[3] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Neurosurg, Seoul, South Korea
[4] Seoul Natl Univ, Med Res Ctr, Neurosci Res Inst, Seoul, South Korea
来源：
NEUROCHEMICAL RESEARCH | 2008年 / 33卷 / 01期
关键词：
interleukin-18; receptor; kainic acid; microglia; astrocyte;
D O I：
10.1007/s11064-007-9434-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Interleukin (IL)-18, a member of the IL-1 cytokine family, is an important mediator of peripheral inflammation and host defence responses. However, although IL-1 is a key proinflammatory cytokine in the brain, little is known about IL-18 changes in glial cells under excitotoxic neurodegeneration. In this study, we characterized the expressions of IL-18 and IL-18 receptor (IL-18R) in kainic acid (KA)-induced excitotoxicity in mouse hippocampus by immunohistochemistry and Western blotting. IL-18 immunoreactivity was found in microglia whereas IL-18R immunoreactivity was observed in astrocytes. Levels of IL-18 and IL-18R in hippocampus homogenates increased progressively from day 1 post-KA and peaked at 3 days. This study demonstrates the cellular sources of IL-18 and IL-18R, and their temporal correlations after KA-insult, and suggests roles for IL-18 and IL-18R in glial cells in response to excitotoxic damage in the hippocampus.
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页码：179 / 184
页数：6
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