Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults

被引:52
作者
de Frias, Cindy M. [1 ]
Bunce, David [2 ]
Wahlin, Ake [1 ]
Adolfsson, Rolf [3 ]
Sleegers, Kristel [4 ]
Cruts, Marc [4 ]
Van Broeckhoven, Christine [4 ]
Nilsson, Lars-Goeran [1 ]
机构
[1] Stockholm Univ, Dept Psychol, Stockholm, Sweden
[2] Brunel Univ, Ctr Cognit & Neuroimaging, Uxbridge UB8 3PH, Middx, England
[3] Umea Univ, Dept Clin Sci & Psychiat, S-90187 Umea, Sweden
[4] Univ Antwerp VIB, Dept Mol Genet, Univ Antwerp, Antwerp, Belgium
来源
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES | 2007年 / 62卷 / 02期
关键词
D O I
10.1093/geronb/62.2.P112
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
We used data from the Betula Study to examine associations between total cholesterol, triglycerides, and apolipoprotein E on 10-year changes in cognitive performance. Tests assessing episodic memory (recall and recognition), semantic memory (knowledge and fluency), and visuospatial ability (block design) were administered to 524 nondemented adults (initial age of 55-80 years); multilevel modeling was applied to the data. Higher triglyceride levels were associated with a decline in verbal knowledge. Lipid levels moderated the influence of apolipoprotein E on episodic memory, such that among epsilon 4 allele carriers, decline in recognition was noted for individuals with higher cholesterol levels. Cholesterol and triglyceride levels are pharmacologically modifiable risk factors that account for variation In normal cognitive aging.
引用
收藏
页码:P112 / P118
页数:7
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