Engineering N-glycosylation pathways in the baculovirus-insect cell system

被引：78

作者：

Jarvis, DL ^{[1
]}

Kawar, ZS ^{[1
]}

Hollister, JR ^{[1
]}

机构：

[1] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1998年 / 9卷 / 05期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0958-1669(98)80041-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The inability to produce eukaryotic glycoproteins with complex N-linked glycans is a major limitation of the baculovirus-insect cell expression system. Recent studies have demonstrated that metabolic engineering can be used to extend the glycoprotein processing capabilities of lepidopteran insect cells. This approach is being used to develop new baculovirus-insect cell expression systems that can produce more authentic recombinant glycoproteins and obtain new information on insect N-glycosylation pathways.

引用

收藏

页码：528 / 533

页数：6

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