Comparison of endothelium-derived relaxing factor activity between nonpregnant and pregnant rats

被引：18

作者：

Honda, H ^{[1
]}

Kaneko, H ^{[1
]}

Kondo, M ^{[1
]}

Kogo, H ^{[1
]}

机构：

[1] GRELAN PHARMACEUTICAL CO LTD,RES CTR,TOKYO 205,JAPAN

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1996年 / 114卷 / 03期

关键词：

pregnancy; EDRF; nitric oxide; aorta; acetylcholine; norepinephrine; estradiol; progesterone; rat;

D O I：

10.1016/0742-8413(96)00040-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tension of isolated ring preparation of aorta from nonpregnant and pregnant rats was measured isometrically to study the effect of pregnancy on endothelium-derived relaxing factor activity. Contraction in response to norepinephrine and potassium chloride was greater in aortae from nonpregnant rats than in those from pregnant rats. The endothelium-dependent relaxation that was caused by acetylcholine (10(-10)-3 X 10(-9) M) in aortae precontracted with norepinephrine was significantly enhanced in aortae from pregnant rats compared with the relaxation in those from nonpregnant rats. N-G-nitro-L-arginine methyl ester (L-NAME) inhibited the endothelium-dependent relaxation in both aorta from pregnant and nonpregnant rats. L-Arginine reversed the inhibition of L-NAME. Those results suggest that the enhanced endothelium-derived relaxing factor activity in rats aortae is associated with pregnancy.

引用

页码：193 / 196

页数：4

共 20 条

[1] THE ROLE OF ENDOTHELIUM IN PHENYLEPHRINE-INDUCED AND POTASSIUM-INDUCED CONTRACTIONS OF THE RAT AORTA DURING PREGNANCY [J].