1,5-benzodithiepan-3-one 1,5-dioxide: A novel chiral auxiliary for asymmetric desymmetrization of meso-1,2-diols

被引：20

作者：

Maezaki, N

Sakamoto, A

Soejima, M

Sakamoto, I

Xia, LY

Tanaka, T

Ohishi, H

Sakaguchi, K

Iwata, C

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV PHARMACEUT SCI,TAKATSUKI,OSAKA 56911,JAPAN

[3] OSAKA UNIV,INST PROT RES,RES CTR PROT ENGN,SUITA,OSAKA 565,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 10期

关键词：

D O I：

10.1016/0957-4166(96)00362-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel C-2-symmetric bis-sulfoxide 1 was synthesized as a chiral auxiliary for asymmetric desymmetrization of meso-1,2-diols, cis-Cyclohexane-l,2-diol and cis-cyclopentane-1,2-diol were desymmetrized via acetalization with 1 followed by base-promoted acetal cleavage with high diastereoselectivity (>96% d.e.). Copyright (C) 1996 Published by Elsevier Science Ltd

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页码：2787 / 2790

页数：4

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