Spermatogenesis: its regulation by testosterone and FSH

被引：109

作者：

Zirkin, BR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Div Reprod Biol, Baltimore, MD 21205 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1998年 / 9卷 / 04期

关键词：

spermatogenesis; testosterone FSH;

D O I：

10.1006/scdb.1998.0253

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

It has been clear for decades that testosterone is a necessary prerequisite for the maintenance of established spermatogenesis in the adult testes, and for the restoration of spermatogenesis in testes induced experimentally to become azoospermic. In contrast, the possible involvement of FSH in regulating spermatogenesis in the adult mammal, though also studied extensively, continues to be debated in the literature. The mechanisms by which testosterone and FSH regulate spermatogenesis remain uncertain as well. This review focuses on our current understanding of the involvement of testosterone and of FSH in the maintenance and restoration of spermatogenesis in the adult testes, and discusses the emerging concept that testosterone and FSH serve as cell survival factors.

引用

页码：417 / 421

页数：5

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