Genetic pathways and histogenetic models of AIDS-related lymphomas

被引：17

作者：

Carbone, A

Gloghini, A

Capello, D

Gaidano, G

机构：

[1] Ist Nazl Tumori, IRCCS, Ctr Riferimento Oncol, Div Pathol, I-33081 Aviano, Italy

[2] Ist Nazl Tumori, IRCCS, Ctr Riferimento Oncol, Sci Direct, I-33081 Aviano, Italy

[3] Univ Piemonte Orientale, Dept Med Sci Amedeo Avogadro, Dept Med Sci, Div Internal Med, Novara, Italy

来源：

EUROPEAN JOURNAL OF CANCER | 2001年 / 37卷 / 10期

关键词：

AIDS; lymphomas; pathogenesis; histogenesis;

D O I：

10.1016/S0959-8049(01)00119-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1270 / 1275

页数：6

共 49 条

[1] THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE [J].