Ion pump sorting in polarized renal epithelial cells

被引：9

作者：

Caplan, MJ ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

来源：

KIDNEY INTERNATIONAL | 2001年 / 60卷 / 02期

关键词：

Na; K-ATPase; H; cell polarity; sorting; protein transport; solute and fluid transport; tight junction;

D O I：

10.1046/j.1523-1755.2001.060002427.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The plasma membranes of renal epithelial cells are divided into distinct apical and basolateral domains, which contain different inventories of ion transport proteins. Without this polarity vectorial ion and fluid transport would not be possible. Little is known of the signals and mechanisms that renal epithelial cells use to establish and maintain polarized distributions of their ion transport proteins. Analysis of ion pump sorting reveals that multiple complex signals participate in determining and regulating these proteins' subcellular localizations.

引用

页码：427 / 430

页数：4

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