Novel membranes for simulating biological barrier transport

被引：10

作者：

Ghosh, R ^{[1
]}

机构：

[1] Univ Oxford, Dept Engn Sci, Oxford OX1 3PJ, England

来源：

JOURNAL OF MEMBRANE SCIENCE | 2001年 / 192卷 / 1-2期

关键词：

biological barrier; transport; supported liquid membrane; simulation; microporous membrane;

D O I：

10.1016/S0376-7388(01)00477-X

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The preparation of a novel type of artificial membrane using microporous membranes as scaffold material is discussed in this paper. A solvent displacement technique was used to prepare supported liquid membranes having parallel water and organic solvent filled pores. These membranes can potentially be used to simulate biological barrier transport processes. Simple permeability prediction studies showed that the effects of solute molar volume and octanol-water partition coefficient on solute transport through these membranes are similar to those observed with certain biological barriers. Experimental studies carried out using model hydrophilic and hydrophobic compounds supported theoretically predicted trends. (C) 2001 Elsevier Science B.V. All rights reserved.

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收藏

页码：145 / 154

页数：10

相关论文

共 24 条

[1] ETHER WATER PARTITIONING AND PERMEABILITY THROUGH NUDE-MOUSE SKIN INVITRO .2. HYDROCORTISONE 21-NORMAL-ALKYL ESTERS, ALKANOLS AND HYDROPHILIC COMPOUNDS [J].

ACKERMANN, C ;

FLYNN, GL ;

SMITH, WM .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 36 (01) :67-71

[2] ETHER WATER PARTITIONING AND PERMEABILITY THROUGH NUDE-MOUSE SKIN INVITRO .1. UREA, THIOUREA, GLYCEROL AND GLUCOSE [J].

ACKERMANN, C ;

FLYNN, GL .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 36 (01) :61-66

[3] TRANSPORT OF PROTEINS DISSOLVED IN ORGANIC-SOLVENTS ACROSS BIOMIMETIC MEMBRANES [J].

BROMBERG, LE ;

KLIBANOV, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) :1262-1266

[4] Shapes of membrane permeability-lipophilicity curves: Extension of theoretical models with an aqueous pore pathway [J].

Camenisch, G ;

Folkers, G ;

van de Waterbeemd, H .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 6 (04) :321-329

[5] Topical delivery of caffeine from some commercial formulations [J].

Dias, M ;

Farinha, A ;

Faustino, E ;

Hadgraft, J ;

Pais, J ;

Toscano, C .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1999, 182 (01) :41-47

[6] Modeling of percutaneous drug transport in vitro using skin-imitating Carbosil membrane [J].

Feldstein, MM ;

Raigorodskii, IM ;

Iordanskii, AL ;

Hadgraft, J .

JOURNAL OF CONTROLLED RELEASE, 1998, 52 (1-2) :25-40

[7] PREDICTION OF SKIN PERMEABILITY OF DRUGS .1. COMPARISON WITH ARTIFICIAL MEMBRANE [J].

HATANAKA, T ;

INUMA, M ;

SUGIBAYASHI, K ;

MORIMOTO, Y .

CHEMICAL & PHARMACEUTICAL BULLETIN, 1990, 38 (12) :3452-3459

[8] Ceramic membrane characterization via the bubble point technique [J].

Jakobs, E ;

Koros, WJ .

JOURNAL OF MEMBRANE SCIENCE, 1997, 124 (02) :149-159

[9] PERMEATION OF MOUSE SKIN AND SILICONE-RUBBER MEMBRANES BY PHENOLS - RELATIONSHIP TO INVITRO PARTITIONING [J].

JETZER, WE ;

HUQ, AS ;

HO, NFH ;

FLYNN, GL ;

DURAISWAMY, N ;

CONDIE, L .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1986, 75 (11) :1098-1103

[10] Evaluation of solute permeation through the stratum corneum: Lateral bilayer diffusion as the primary transport mechanism [J].

Johnson, ME ;

Blankschtein, D ;

Langer, R .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (10) :1162-1172