Screening for cancer with molecular markers: progress comes with potential problems

被引：36

作者：

Baron, John A. ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC 27599 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 05期

关键词：

OVARIAN-CANCER; PROSTATE-CANCER; BREAST-CANCER; CARCINOEMBRYONIC ANTIGEN; GASTROINTESTINAL CANCER; COLORECTAL-CANCER; AUTOPSY SERIES; LUNG-CANCER; OBESE MEN; SERUM;

D O I：

10.1038/nrc3260

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Recent research has raised hopes for impressively accurate screening for cancer with molecular biomarkers. These molecular markers will probably be more sensitive and specific than older screening modalities, as well as easier to use. In this Essay, I argue that these sensitive screening tests might be clinically valuable-but that they will present unique issues in implementation and interpretation. These issues are likely to affect the way clinicians conduct screening and the way that they make diagnoses in individuals who screen positive for cancer.

引用

页码：368 / 371

页数：5

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