The effect of genotype and pedigree error on linkage analysis: Analysis of three asthma genome scans

被引：18

作者：

Cherny, SS

Abecasis, GR

Cookson, WOC

Sham, PC

Cardon, LR

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[2] Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London, England

[3] Inst Psychiat, Dept Psychiat, London SE5 8AF, England

来源：

GENETIC EPIDEMIOLOGY | 2001年 / 21卷

关键词：

asthma; genome scan; genotype error; linkage; pedigree error;

D O I：

10.1002/gepi.2001.21.s1.s117

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effects of genotype and relationship errors on linkage results are evaluated in three of the Genetic Analysis Workshop 12 asthma genome scans. A number of errors are detected in the samples. While the evidence for linkage is not striking in any data set with or without error, in some cases the difference in test statistic could support different conclusions. The results provide empirical evidence for the predicted effects of genotype and relationship error and highlight the need for rigorous detection and elimination of data error in complex trait studies. (C) 2001 Wiley-Liss, Inc.

引用

页码：S117 / S122

页数：6

共 8 条

[1]

Abecasis GR, 2000, AM J HUM GENET, V67, P327

[2] The impact of genotyping error on family-based analysis of quantitative traits [J].